United have opened their Premier League campaign with two consecutive 1-0 victories over Tottenham and Aston Villa, before kicking off their Champions League campaign with an impressive 3-1 victory over Club Brugge on Tuesday.
Manager Louis van Gaal will be hoping for a positive end to the week after reported target Pedro signed for Chelsea on Thursday.
Standing in their way is a new-look Newcastle side who have made a tentative start to life under Steve McClaren. The Magpies have claimed just one point from their opening two league outings, with their latest result a 2-0 defeat to Swansea.
McClaren will be boosted by the addition of Florian Thauvin, who completed his move from Marseille to St James' Park on Wednesday.
Team news
Sergio Romero will continue in goal for United as David de Gea is still unable to focus on playing following Real Madrid's interest, according to Van Gaal.
The United manager remains without centre-back Phil Jones (mild thrombosis) and defender Marcos Rojo is unlikely to feature as he lacks match sharpness.
Van Gaal is considering handing Bastian Schweinsteiger his first start, but fellow midfielder Marouane Fellaini is still suspended.
New signing Thauvin goes straight into the squad for Newcastle's trip to Old Trafford. The 22-year-old is included just days after completing his switch to Tyneside, and he could yet be joined by fellow midfielder Moussa Sissoko, who is recovering well from a groin problem which forced his premature withdrawal at Swansea last weekend, but the France international remains a doubt.
Holland midfielder Siem de Jong is back in training after a shin injury, as is defender Paul Dummett, who is yet to feature this season because of a hamstring problem, but full-back Daryl Janmaat is suspended following his red card at the Liberty Stadium.
Newcastle have only enjoyed one Premier League victory at Old Trafford in their 21 visits, with a 1-0 win coming in December 2013 (D7 L13).
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